EIF2S1_phosphorylated -> EIF2_P_GDP_complex
EIF2S2 -> EIF2_P_GDP_complex
EIF2S3_GDP_complex -> EIF2_P_GDP_complex
ERN1_Unfolded_space_protein_complex -> TRAF2_ERN1_complex
path_0_sa204_TRAF2_Cytoplasm -> TRAF2_ERN1_complex
BAK1_ERN1_complex -> TRAF2_ERN1_complex
BAX_ERN1_complex -> TRAF2_ERN1_complex
BCL2 -| TRAF2_ERN1_complex
BCL2L1 -| TRAF2_ERN1_complex
Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum -| TRAF2_ERN1_complex
BAX_Endoplasmic_Reticulum -> TRAF2_ERN1_complex
BAK1 -> TRAF2_ERN1_complex
SIGMAR1_MAM__mito_associated_ER_membrane_ -> SIGMAR1_ITPR3_complex
ITPR3 -> SIGMAR1_ITPR3_complex
ER_space_stress_phenotype -> SIGMAR1_ITPR3_complex
Ca2_space_ER_space_depletion_phenotype -> SIGMAR1_ITPR3_complex
Met_tRNA_rna -> EIF2_GDP_Met_tRNA_complex
EIF2_GDP_complex -> EIF2_GDP_Met_tRNA_complex
Ternary_space_Complex_complex -> EIF2_GDP_Met_tRNA_complex
path_0_sa103_GDP_simple_molecule_Cytoplasm -> EIF2_GDP_Met_tRNA_complex
CASP8_CASP8_ubq_FADD_complex -> CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex
SQSTM1_space_ -> CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex
MAP1LC3A -> CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex
ATG5 -> CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex
TRIM13 -> CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex
Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum -> CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex
path_0_sa1_ERN1_Endoplasmic_Reticulum -> ERN1_Unfolded_space_protein_complex
path_0_sa203_Unfolded_space_protein_Endoplasmic_Reticulum -> ERN1_Unfolded_space_protein_complex
path_1_sa87_HSPA5_Endoplasmic_Reticulum -> SIGMAR1_HSPA5_complex
SIGMAR1_Endoplasmic_Reticulum -> SIGMAR1_HSPA5_complex
VAPB -> VAPB_RMDN3_complex
RMDN3 -> VAPB_RMDN3_complex
EIF2_GDP_Met_tRNA_complex -> Ternary_space_Complex_complex
path_0_sa102_GTP_simple_molecule_Cytoplasm -> Ternary_space_Complex_complex
EIF2B_complex -> Ternary_space_Complex_complex
PACS2_early_space_endosome -> PACS2_ADAM17_space_interaction_complex
ADAM17_early_space_endosome -> PACS2_ADAM17_space_interaction_complex
BCAP31 -> FIS1_BCAP31_complex
FIS1 -> FIS1_BCAP31_complex
MFN2_Endoplasmic_Reticulum -> MFN2_MFN2_complex
MFN2_mitochondrion_outer_space_membrane -> MFN2_MFN2_complex
path_0_sa617_ERN1_Endoplasmic_Reticulum -> ERN1_BBC3_complex
BBC3 -> ERN1_BBC3_complex
Persistant_space_ER_space_Stress_phenotype_Cytoplasm -| ERN1_BBC3_complex
EIF2S2 -> EIF2_GDP_complex
EIF2S3_GDP_complex -> EIF2_GDP_complex
EIF2S1 -> EIF2_GDP_complex
MFN2_Endoplasmic_Reticulum -> MFN1_MFN2_complex
MFN1 -> MFN1_MFN2_complex
MCU -> MCU_MICU1_MICU2_SMDT1_complex
SMDT1 -> MCU_MICU1_MICU2_SMDT1_complex
MCU2 -> MCU_MICU1_MICU2_SMDT1_complex
MCU1 -> MCU_MICU1_MICU2_SMDT1_complex
path_0_sa617_ERN1_Endoplasmic_Reticulum -> ERN1_BCL2L11_complex
BCL2L11_Endoplasmic_Reticulum -> ERN1_BCL2L11_complex
Persistant_space_ER_space_Stress_phenotype_Cytoplasm -| ERN1_BCL2L11_complex
CAPN1 -> CAPN1_Ca2__complex
Ca2__ion_Cytoplasm -> CAPN1_Ca2__complex
high_space_Ca2_space_cytosolic_space_concentration_phenotype -> CAPN1_Ca2__complex
EIF2AK3 -> EIF2AK3_EIF2AK3_complex
path_0_sa5_Unfolded_space_protein_Endoplasmic_Reticulum -> EIF2AK3_EIF2AK3_complex
Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum -> EIF2AK3_EIF2AK3_complex
MCU_MICU1_MICU2_SMDT1_complex -> Mitochondrial_space_calcium_space_uniporter_space_complex_complex
ACE2 -> ACE2_Spike_complex
sa258_S_default_compartment -> ACE2_Spike_complex
sa258_S_default_compartment -> HSPA5_Spike_interaction_complex
HSPA5_default_compartment -> HSPA5_Spike_interaction_complex
ACE2__space_membrane_bound -> ACE2_SARS_CoV_interaction_complex
sa275_S_default_compartment -> ACE2_SARS_CoV_interaction_complex
ACE2__space_soluble -| ACE2_SARS_CoV_interaction_complex
PPP1R15A_gene -> PPP1R15A_rna
ATF4 -> PPP1R15A_rna
path_0_sa69_DDIT3_Cytoplasm -> PPP1R15A_rna
BAX_phosphorylated -> release_space_of_space_ER_space_Ca2__phenotype
ATF6_Endoplasmic_Reticulum -> path_0_sa57_ATF6_Golgi
ER_space_Stress_phenotype -> path_0_sa57_ATF6_Golgi
retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype -| path_0_sa57_ATF6_Golgi
path_0_sa629_DDIT3_Cytoplasm -> path_0_sa630_DDIT3_phosphorylated_Cytoplasm
path_0_sa43_MAPK14_phosphorylated_Cytoplasm -> path_0_sa630_DDIT3_phosphorylated_Cytoplasm
MFN2_Endoplasmic_Reticulum -> endoplasmic_space_reticulum_space_organization_phenotype
ATF6_HSPA5_complex -> path_0_sa4_HSPA5_Endoplasmic_Reticulum
path_0_sa618_Unfolded_space_protein_Endoplasmic_Reticulum -> path_0_sa4_HSPA5_Endoplasmic_Reticulum
path_0_sa582_ITPR_Endoplasmic_Reticulum -> path_0_sa583_ITPR_Endoplasmic_Reticulum
TMBIM6 -> path_0_sa583_ITPR_Endoplasmic_Reticulum
path_0_sa625_ERO1A_Endoplasmic_Reticulum -> path_0_sa583_ITPR_Endoplasmic_Reticulum
Ternary_space_Complex_complex -> path_0_sa95_GTP_simple_molecule_Cytoplasm
path_0_sa103_GDP_simple_molecule_Cytoplasm -> path_0_sa95_GTP_simple_molecule_Cytoplasm
path_0_sa69_DDIT3_Cytoplasm -> path_0_sa46_DDIT3_phosphorylated_Cytoplasm
path_0_sa620_MAPK14_phosphorylated_Cytoplasm -> path_0_sa46_DDIT3_phosphorylated_Cytoplasm
SIGMAR1_HSPA5_complex -> path_1_sa87_HSPA5_Endoplasmic_Reticulum
ER_space_stress_phenotype -> path_1_sa87_HSPA5_Endoplasmic_Reticulum
Ca2_space_ER_space_depletion_phenotype -> path_1_sa87_HSPA5_Endoplasmic_Reticulum
HSPA5_rna -> path_1_sa87_HSPA5_Endoplasmic_Reticulum
ACE2 -| path_1_sa87_HSPA5_Endoplasmic_Reticulum
HSPA5_gene -> HSPA5_rna
ACE2 -| HSPA5_rna
sa275_S_default_compartment -> HSPA5_rna
path_0_sa626_XBP1_Cytoplasm -> UPR_phenotype
TRAF2_ERN1_complex -> UPR_phenotype
accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype -> UPR_phenotype
path_0_sa64_ATF6_Golgi -> UPR_phenotype
EIF2AK3_EIF2AK3_complex -> UPR_phenotype
FIS1 -> Ca2_space_mitochondrial_space_concentration_phenotype
VAPB -> Ca2_space_mitochondrial_space_concentration_phenotype
RMDN3 -> Ca2_space_mitochondrial_space_concentration_phenotype
PACS2_Endoplasmic_Reticulum -| mitochondrial_space_fission_phenotype
path_0_sa119_TRAF2_Cytoplasm -> path_0_sa118_TRAF2_Cytoplasm
TRAF2_ERN1_complex -> path_0_sa118_TRAF2_Cytoplasm
accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype -> ER_space_Stress_phenotype
ATF6_HSPA5_complex -> ATF6_Endoplasmic_Reticulum
path_0_sa618_Unfolded_space_protein_Endoplasmic_Reticulum -> ATF6_Endoplasmic_Reticulum
DDIT3_gene -> DDIT3_rna
ATF6_Nucleus -> DDIT3_rna
ATF4 -> DDIT3_rna
Persistant_space_ER_space_Stress_phenotype_Cytoplasm -> DDIT3_rna
path_0_sa26_XBP1_Cytoplasm -> DDIT3_rna
ATF4_gene -> ATF4_rna
EIF2_P_GDP_complex -> ATF4_rna
BCL2L11_phosphorylated -> BCL2L11_Cytoplasm
PPP2CA -> BCL2L11_Cytoplasm
TRIB3_gene -> TRIB3_rna
path_0_sa69_DDIT3_Cytoplasm -> TRIB3_rna
path_1_sa54_Ca2__ion_Endoplasmic_Reticulum -> path_1_sa55_Ca2__ion_mitochondrion_outer_space_membrane
ITPR3_HSPA9_VDAC1_complex -> path_1_sa55_Ca2__ion_mitochondrion_outer_space_membrane
SIGMAR1_ITPR3_complex -> path_1_sa55_Ca2__ion_mitochondrion_outer_space_membrane
EIF2S1_phosphorylated -> EIF2S1
PPP1R15A -> EIF2S1
EIF2AK1 -> EIF2S1
CASP9 -> cleaved_CASP9
cleaved_CASP4 -> cleaved_CASP9
ERO1A_Cytoplasm -> path_0_sa212_ERO1A_Endoplasmic_Reticulum
RMDN3 -| autophagy_phenotype
VAPB -| autophagy_phenotype
ITPR3 -| autophagy_phenotype
mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype -| autophagy_phenotype
PPP1R15A_rna -> PPP1R15A
mitochondrial_space_fission_phenotype -> mitochondria_space_fragmentation_phenotype
FIS1 -> mitochondrial_space_outer_space_membrane_space_depolarization_phenotype
SIGMAR1_HSPA5_complex -> SIGMAR1_MAM__mito_associated_ER_membrane_
ER_space_stress_phenotype -> SIGMAR1_MAM__mito_associated_ER_membrane_
Ca2_space_ER_space_depletion_phenotype -> SIGMAR1_MAM__mito_associated_ER_membrane_
XBP1_gene -> XBP1_rna
ATF6_Nucleus -> XBP1_rna
TRAF2_ERN1_complex -> XBP1_rna
ERN1_BBC3_complex -> XBP1_rna
ERN1_BCL2L11_complex -> XBP1_rna
path_0_sa5_Unfolded_space_protein_Endoplasmic_Reticulum -> accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype
ERAD_phenotype -> accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype
BCL2_gene -> BCL2_rna
path_0_sa46_DDIT3_phosphorylated_Cytoplasm -| BCL2_rna
path_0_sa212_ERO1A_Endoplasmic_Reticulum -> hyperoxidation_phenotype
retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype -> protein_space_ubiquitination_space_and_space_destruction_phenotype
MAPK14 -> path_0_sa43_MAPK14_phosphorylated_Cytoplasm
MAP3K5_phosphorylated -> path_0_sa43_MAPK14_phosphorylated_Cytoplasm
ERO1A_rna -> ERO1A_Cytoplasm
Apoptosis_phenotype_Cytoplasm -> Cell_space_survival_phenotype
ER_space_stress_phenotype -> unfolded_space_protein_space_response_space__UPR__phenotype
MFN2_Endoplasmic_Reticulum -> unfolded_space_protein_space_response_space__UPR__phenotype
p20 -> unfolded_space_protein_space_response_space__UPR__phenotype
path_0_sa287_EIF2AK2_Cytoplasm -> path_0_sa210_EIF2AK2_Cytoplasm
presence_space_of_space_dsRNA_phenotype -> path_0_sa210_EIF2AK2_Cytoplasm
path_0_sa624_DNAJC3_Cytoplasm -| path_0_sa210_EIF2AK2_Cytoplasm
path_1_sa63_Ca2__ion_mitochondrion_outer_space_membrane -> Ca2__ion_mitochondrion_inner_space_membrane
Mitochondrial_space_calcium_space_uniporter_space_complex_complex -> Ca2__ion_mitochondrion_inner_space_membrane
BAX_Cytoplasm -> BAX_phosphorylated
MAPK8_phosphorylated -> BAX_phosphorylated
path_0_sa43_MAPK14_phosphorylated_Cytoplasm -> BAX_phosphorylated
ATF6_Endoplasmic_Reticulum -> retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype
EIF2AK3_EIF2AK3_complex -> retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype
MAPK8 -> MAPK8_phosphorylated
MAP3K4_phosphorylated -> MAPK8_phosphorylated
MAP3K5_phosphorylated -> MAPK8_phosphorylated
Ternary_space_Complex_complex -> Translation_space_initiation_phenotype
BID -> BID_phosphorylated
MAPK8_phosphorylated -> BID_phosphorylated
path_0_sa62_ATF6_Golgi -> path_0_sa64_ATF6_Golgi
MBTPS2 -> path_0_sa64_ATF6_Golgi
TRIB3_rna -> path_0_sa486_TRIB3_Cytoplasm
path_0_sa147_CDK5_Cytoplasm -> path_0_sa146_CDK5_Cytoplasm
ER_space_Stress_phenotype -> path_0_sa146_CDK5_Cytoplasm
DNAJC3_rna -> path_0_sa515_DNAJC3_Cytoplasm
CASP4 -> cleaved_CASP4
CAPN1_Ca2__complex -> cleaved_CASP4
MFN2_Endoplasmic_Reticulum -> ER_space_stress_phenotype
ACE2 -| ER_space_stress_phenotype
SIGMAR1_MAM__mito_associated_ER_membrane_ -| ER_space_stress_phenotype
HYOU1_rna -> HYOU1
CASP3 -> cleaved_CASP3
cleaved_CASP4 -> cleaved_CASP3
EIF2S1 -> EIF2S1_phosphorylated
EIF2AK3_EIF2AK3_complex -> EIF2S1_phosphorylated
GCN2_ATP_complex -> EIF2S1_phosphorylated
path_0_sa210_EIF2AK2_Cytoplasm -> EIF2S1_phosphorylated
path_0_sa515_DNAJC3_Cytoplasm -| EIF2S1_phosphorylated
VAPB_RMDN3_complex -> mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype
MFN2_MFN2_complex -> mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype
FIS1_BCAP31_complex -> mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype
MFN1_MFN2_complex -> mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype
PACS2_Endoplasmic_Reticulum -> mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype
AP_1 -> AP_1_phosphorylated_phosphorylated
MAPK8_phosphorylated -> AP_1_phosphorylated_phosphorylated
path_0_sa629_DDIT3_Cytoplasm -> AP_1_phosphorylated_phosphorylated
EIF2_GDP_Met_tRNA_complex -> path_0_sa100_GDP_simple_molecule_Cytoplasm
path_0_sa102_GTP_simple_molecule_Cytoplasm -> path_0_sa100_GDP_simple_molecule_Cytoplasm
EIF2B_complex -> path_0_sa100_GDP_simple_molecule_Cytoplasm
path_0_sa163_Ca2__ion_Endoplasmic_Reticulum -> Ca2__ion_Cytoplasm
TMBIM6 -> Ca2__ion_Cytoplasm
RYR1 -> Ca2__ion_Cytoplasm
path_0_sa583_ITPR_Endoplasmic_Reticulum -> Ca2__ion_Cytoplasm
BCAP31 -> p20
PACS2_Endoplasmic_Reticulum -| p20
Apoptosis_phenotype_Endoplasmic_Reticulum -> p20
ATF4_rna -> ATF4
MAP3K5 -> MAP3K5_phosphorylated
path_0_sa118_TRAF2_Cytoplasm -> MAP3K5_phosphorylated
TRAF2_ERN1_complex -> MAP3K5_phosphorylated
MFN2_Endoplasmic_Reticulum -> Apoptosis_phenotype_Endoplasmic_Reticulum
ER_space_stress_phenotype -> Apoptosis_phenotype_Endoplasmic_Reticulum
SIGMAR1_MAM__mito_associated_ER_membrane_ -| Apoptosis_phenotype_Endoplasmic_Reticulum
DNAJC3_gene -> DNAJC3_rna
ATF6_Nucleus -> DNAJC3_rna
path_0_sa57_ATF6_Golgi -> path_0_sa62_ATF6_Golgi
MBTPS1 -> path_0_sa62_ATF6_Golgi
MFN2_rna -> MFN2_Endoplasmic_Reticulum
ER_space_stress_phenotype -> MFN2_Endoplasmic_Reticulum
PACS2_ADAM17_space_interaction_complex -> ADAM17_Cytoplasm
path_0_sa627_XBP1_Cytoplasm -> ERAD_phenotype
MFN2_gene -> MFN2_rna
cleaved_CASP9 -> Apoptosis_phenotype_Cytoplasm
cleaved_CASP3 -> Apoptosis_phenotype_Cytoplasm
CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex -> Apoptosis_phenotype_Cytoplasm
sa257_TRIB3_Cytoplasm -> Apoptosis_phenotype_Cytoplasm
Cell_space_survival_phenotype -> Apoptosis_phenotype_Cytoplasm
path_0_sa630_DDIT3_phosphorylated_Cytoplasm -> Apoptosis_phenotype_Cytoplasm
BCL2L11_phosphorylated -> Apoptosis_phenotype_Cytoplasm
BAX_phosphorylated -> Apoptosis_phenotype_Cytoplasm
path_0_sa43_MAPK14_phosphorylated_Cytoplasm -> Apoptosis_phenotype_Cytoplasm
BID_phosphorylated -> Apoptosis_phenotype_Cytoplasm
Mitochondrial_space_calcium_space_uniporter_space_complex_complex -> mitochondrial_space_calcium_space_ion_space_transmembrane_space_transport_phenotype
ACE2 -> ACE2__space_soluble
ADAM17_Cytoplasm -> ACE2__space_soluble
ER_space_Stress_phenotype -> Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum
DDIT3_rna -> path_0_sa69_DDIT3_Cytoplasm
release_space_of_space_ER_space_Ca2__phenotype -> high_space_Ca2_space_cytosolic_space_concentration_phenotype
Ca2__ion_Cytoplasm -> high_space_Ca2_space_cytosolic_space_concentration_phenotype
XBP1_rna -> path_0_sa26_XBP1_Cytoplasm
path_0_sa64_ATF6_Golgi -> ATF6_Nucleus
MFN2_Endoplasmic_Reticulum -> endoplasmic_space_reticulum_space_calcium_space_ion_space_homeostasis_phenotype
path_1_sa87_HSPA5_Endoplasmic_Reticulum -> endoplasmic_space_reticulum_space_calcium_space_ion_space_homeostasis_phenotype
MAP3K4 -> MAP3K4_phosphorylated
path_0_sa146_CDK5_Cytoplasm -> MAP3K4_phosphorylated
VAPB -| Ca2_space_cytosolic_space_concentration_phenotype
RMDN3 -| Ca2_space_cytosolic_space_concentration_phenotype
HYOU1_gene -> HYOU1_rna
ATF6_Nucleus -> HYOU1_rna
BCL2L11_Cytoplasm -> BCL2L11_phosphorylated
MAPK8_phosphorylated -> BCL2L11_phosphorylated
ERO1A_gene -> ERO1A_rna
path_0_sa69_DDIT3_Cytoplasm -> ERO1A_rna
ATF6_Nucleus -> ERO1A_rna
ACE2 -> ACE2__space_membrane_bound
ADAM17_Cytoplasm -> ACE2__space_membrane_bound
ACE2 -| pulmonary_fibrosis_phenotype
ACE2_SARS_CoV_interaction_complex -> viral_entry_into_host_cell_phenotype
SARS_CoV_infection_phenotype -> viral_entry_into_host_cell_phenotype
ACE2__space_soluble -| viral_entry_into_host_cell_phenotype
HSPA5_Spike_interaction_complex -> viral_entry_into_host_cell_phenotype
viral_entry_into_host_cell_phenotype -| ACE2_rna
ACE2 -> viral_RNA_genome_replication_phenotype
$ACE2_SARS_CoV_interaction_complex: ((ACE2__space_membrane_bound & sa275_S_default_compartment) & !ACE2__space_soluble)
$ACE2_Spike_complex: (ACE2 & sa258_S_default_compartment)
$ACE2__space_membrane_bound: (ACE2 & ADAM17_Cytoplasm)
$ACE2__space_soluble: (ACE2 & ADAM17_Cytoplasm)
$ACE2_rna: !viral_entry_into_host_cell_phenotype
$ADAM17_Cytoplasm: PACS2_ADAM17_space_interaction_complex
$AP_1_phosphorylated_phosphorylated: ((MAPK8_phosphorylated | path_0_sa629_DDIT3_Cytoplasm) & AP_1)
$ATF4: ATF4_rna
$ATF4_rna: (ATF4_gene & EIF2_P_GDP_complex)
$ATF6_Endoplasmic_Reticulum: (ATF6_HSPA5_complex & path_0_sa618_Unfolded_space_protein_Endoplasmic_Reticulum)
$ATF6_Nucleus: path_0_sa64_ATF6_Golgi
$Apoptosis_phenotype_Cytoplasm: (((((((((cleaved_CASP9 | cleaved_CASP3) | CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex) | sa257_TRIB3_Cytoplasm) | Cell_space_survival_phenotype) | path_0_sa630_DDIT3_phosphorylated_Cytoplasm) | BCL2L11_phosphorylated) | BAX_phosphorylated) | path_0_sa43_MAPK14_phosphorylated_Cytoplasm) | BID_phosphorylated)
$Apoptosis_phenotype_Endoplasmic_Reticulum: ((MFN2_Endoplasmic_Reticulum | ER_space_stress_phenotype) | !SIGMAR1_MAM__mito_associated_ER_membrane_)
$BAX_phosphorylated: ((MAPK8_phosphorylated | path_0_sa43_MAPK14_phosphorylated_Cytoplasm) & BAX_Cytoplasm)
$BCL2L11_Cytoplasm: (BCL2L11_phosphorylated & PPP2CA)
$BCL2L11_phosphorylated: (BCL2L11_Cytoplasm & MAPK8_phosphorylated)
$BCL2_rna: (BCL2_gene & !path_0_sa46_DDIT3_phosphorylated_Cytoplasm)
$BID_phosphorylated: (BID & MAPK8_phosphorylated)
$CAPN1_Ca2__complex: ((CAPN1 & Ca2__ion_Cytoplasm) & high_space_Ca2_space_cytosolic_space_concentration_phenotype)
$CASP8_FADD_MAP1LC3A_SQSTM1_ATG5_complex: (((((TRIM13 | Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum) & CASP8_CASP8_ubq_FADD_complex) & SQSTM1_space_) & MAP1LC3A) & ATG5)
$Ca2__ion_Cytoplasm: (((TMBIM6 | RYR1) | path_0_sa583_ITPR_Endoplasmic_Reticulum) & path_0_sa163_Ca2__ion_Endoplasmic_Reticulum)
$Ca2__ion_mitochondrion_inner_space_membrane: (path_1_sa63_Ca2__ion_mitochondrion_outer_space_membrane & Mitochondrial_space_calcium_space_uniporter_space_complex_complex)
$Ca2_space_cytosolic_space_concentration_phenotype: (!VAPB | !RMDN3)
$Ca2_space_mitochondrial_space_concentration_phenotype: ((FIS1 | VAPB) | RMDN3)
$Cell_space_survival_phenotype: Apoptosis_phenotype_Cytoplasm
$DDIT3_rna: ((((ATF6_Nucleus | path_0_sa26_XBP1_Cytoplasm) & DDIT3_gene) & ATF4) & Persistant_space_ER_space_Stress_phenotype_Cytoplasm)
$DNAJC3_rna: (DNAJC3_gene & ATF6_Nucleus)
$EIF2AK3_EIF2AK3_complex: ((path_0_sa5_Unfolded_space_protein_Endoplasmic_Reticulum | Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum) & EIF2AK3)
$EIF2S1: ((PPP1R15A | EIF2AK1) & EIF2S1_phosphorylated)
$EIF2S1_phosphorylated: ((((EIF2AK3_EIF2AK3_complex | GCN2_ATP_complex) | path_0_sa210_EIF2AK2_Cytoplasm) & EIF2S1) & !path_0_sa515_DNAJC3_Cytoplasm)
$EIF2_GDP_Met_tRNA_complex: ((Met_tRNA_rna & EIF2_GDP_complex) | (Ternary_space_Complex_complex & path_0_sa103_GDP_simple_molecule_Cytoplasm))
$EIF2_GDP_complex: ((EIF2S2 & EIF2S3_GDP_complex) & EIF2S1)
$EIF2_P_GDP_complex: ((EIF2S1_phosphorylated & EIF2S2) & EIF2S3_GDP_complex)
$ERAD_phenotype: path_0_sa627_XBP1_Cytoplasm
$ERN1_BBC3_complex: ((path_0_sa617_ERN1_Endoplasmic_Reticulum & BBC3) & !Persistant_space_ER_space_Stress_phenotype_Cytoplasm)
$ERN1_BCL2L11_complex: ((path_0_sa617_ERN1_Endoplasmic_Reticulum & BCL2L11_Endoplasmic_Reticulum) & !Persistant_space_ER_space_Stress_phenotype_Cytoplasm)
$ERN1_Unfolded_space_protein_complex: (path_0_sa1_ERN1_Endoplasmic_Reticulum & path_0_sa203_Unfolded_space_protein_Endoplasmic_Reticulum)
$ERO1A_Cytoplasm: ERO1A_rna
$ERO1A_rna: ((path_0_sa69_DDIT3_Cytoplasm | ATF6_Nucleus) & ERO1A_gene)
$ER_space_Stress_phenotype: accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype
$ER_space_stress_phenotype: ((MFN2_Endoplasmic_Reticulum | !ACE2) | !SIGMAR1_MAM__mito_associated_ER_membrane_)
$FIS1_BCAP31_complex: (BCAP31 & FIS1)
$HSPA5_Spike_interaction_complex: (sa258_S_default_compartment & HSPA5_default_compartment)
$HSPA5_rna: ((HSPA5_gene & sa275_S_default_compartment) & !ACE2)
$HYOU1: HYOU1_rna
$HYOU1_rna: (HYOU1_gene & ATF6_Nucleus)
$MAP3K4_phosphorylated: (MAP3K4 & path_0_sa146_CDK5_Cytoplasm)
$MAP3K5_phosphorylated: ((path_0_sa118_TRAF2_Cytoplasm | TRAF2_ERN1_complex) & MAP3K5)
$MAPK8_phosphorylated: ((MAP3K4_phosphorylated | MAP3K5_phosphorylated) & MAPK8)
$MCU_MICU1_MICU2_SMDT1_complex: ((MCU & SMDT1) | (MCU2 & MCU1))
$MFN1_MFN2_complex: (MFN2_Endoplasmic_Reticulum & MFN1)
$MFN2_Endoplasmic_Reticulum: (MFN2_rna & ER_space_stress_phenotype)
$MFN2_MFN2_complex: (MFN2_Endoplasmic_Reticulum & MFN2_mitochondrion_outer_space_membrane)
$MFN2_rna: MFN2_gene
$Mitochondrial_space_calcium_space_uniporter_space_complex_complex: MCU_MICU1_MICU2_SMDT1_complex
$PACS2_ADAM17_space_interaction_complex: (PACS2_early_space_endosome & ADAM17_early_space_endosome)
$PPP1R15A: PPP1R15A_rna
$PPP1R15A_rna: ((ATF4 | path_0_sa69_DDIT3_Cytoplasm) & PPP1R15A_gene)
$Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum: ER_space_Stress_phenotype
$SIGMAR1_HSPA5_complex: (path_1_sa87_HSPA5_Endoplasmic_Reticulum & SIGMAR1_Endoplasmic_Reticulum)
$SIGMAR1_ITPR3_complex: (((ER_space_stress_phenotype | Ca2_space_ER_space_depletion_phenotype) & SIGMAR1_MAM__mito_associated_ER_membrane_) & ITPR3)
$SIGMAR1_MAM__mito_associated_ER_membrane_: ((ER_space_stress_phenotype | Ca2_space_ER_space_depletion_phenotype) & SIGMAR1_HSPA5_complex)
$TRAF2_ERN1_complex: ((((((((BAK1_ERN1_complex | BAX_ERN1_complex) | BAX_Endoplasmic_Reticulum) | BAK1) & ERN1_Unfolded_space_protein_complex) & path_0_sa204_TRAF2_Cytoplasm) & !BCL2) & !BCL2L1) & !Persistant_space_ER_space_Stress_phenotype_Endoplasmic_Reticulum)
$TRIB3_rna: (TRIB3_gene & path_0_sa69_DDIT3_Cytoplasm)
$Ternary_space_Complex_complex: ((EIF2_GDP_Met_tRNA_complex & path_0_sa102_GTP_simple_molecule_Cytoplasm) & EIF2B_complex)
$Translation_space_initiation_phenotype: Ternary_space_Complex_complex
$UPR_phenotype: ((((path_0_sa626_XBP1_Cytoplasm | TRAF2_ERN1_complex) | accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype) | path_0_sa64_ATF6_Golgi) | EIF2AK3_EIF2AK3_complex)
$VAPB_RMDN3_complex: (VAPB & RMDN3)
$XBP1_rna: ((((ATF6_Nucleus | TRAF2_ERN1_complex) | ERN1_BBC3_complex) | ERN1_BCL2L11_complex) & XBP1_gene)
$accumulation_space_of_space_misfolded_space_protein_space_in_space_ER_phenotype: (path_0_sa5_Unfolded_space_protein_Endoplasmic_Reticulum | ERAD_phenotype)
$autophagy_phenotype: (((!RMDN3 | !VAPB) | !ITPR3) | !mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype)
$cleaved_CASP3: (CASP3 & cleaved_CASP4)
$cleaved_CASP4: (CASP4 & CAPN1_Ca2__complex)
$cleaved_CASP9: (CASP9 & cleaved_CASP4)
$endoplasmic_space_reticulum_space_calcium_space_ion_space_homeostasis_phenotype: (MFN2_Endoplasmic_Reticulum | path_1_sa87_HSPA5_Endoplasmic_Reticulum)
$endoplasmic_space_reticulum_space_organization_phenotype: MFN2_Endoplasmic_Reticulum
$high_space_Ca2_space_cytosolic_space_concentration_phenotype: (release_space_of_space_ER_space_Ca2__phenotype | Ca2__ion_Cytoplasm)
$hyperoxidation_phenotype: path_0_sa212_ERO1A_Endoplasmic_Reticulum
$mitochondria_space_fragmentation_phenotype: mitochondrial_space_fission_phenotype
$mitochondrial_space_calcium_space_ion_space_transmembrane_space_transport_phenotype: Mitochondrial_space_calcium_space_uniporter_space_complex_complex
$mitochondrial_space_fission_phenotype: !PACS2_Endoplasmic_Reticulum
$mitochondrial_space_outer_space_membrane_space_depolarization_phenotype: FIS1
$mitochondrion_endoplasmic_space_reticulum_space_membrane_space_tethering_space__phenotype: ((((VAPB_RMDN3_complex | MFN2_MFN2_complex) | FIS1_BCAP31_complex) | MFN1_MFN2_complex) | PACS2_Endoplasmic_Reticulum)
$p20: ((BCAP31 & Apoptosis_phenotype_Endoplasmic_Reticulum) & !PACS2_Endoplasmic_Reticulum)
$path_0_sa100_GDP_simple_molecule_Cytoplasm: ((EIF2_GDP_Met_tRNA_complex & path_0_sa102_GTP_simple_molecule_Cytoplasm) & EIF2B_complex)
$path_0_sa118_TRAF2_Cytoplasm: (path_0_sa119_TRAF2_Cytoplasm & TRAF2_ERN1_complex)
$path_0_sa146_CDK5_Cytoplasm: (path_0_sa147_CDK5_Cytoplasm & ER_space_Stress_phenotype)
$path_0_sa210_EIF2AK2_Cytoplasm: ((path_0_sa287_EIF2AK2_Cytoplasm & presence_space_of_space_dsRNA_phenotype) & !path_0_sa624_DNAJC3_Cytoplasm)
$path_0_sa212_ERO1A_Endoplasmic_Reticulum: ERO1A_Cytoplasm
$path_0_sa26_XBP1_Cytoplasm: XBP1_rna
$path_0_sa43_MAPK14_phosphorylated_Cytoplasm: (MAPK14 & MAP3K5_phosphorylated)
$path_0_sa46_DDIT3_phosphorylated_Cytoplasm: (path_0_sa69_DDIT3_Cytoplasm & path_0_sa620_MAPK14_phosphorylated_Cytoplasm)
$path_0_sa486_TRIB3_Cytoplasm: TRIB3_rna
$path_0_sa4_HSPA5_Endoplasmic_Reticulum: (ATF6_HSPA5_complex & path_0_sa618_Unfolded_space_protein_Endoplasmic_Reticulum)
$path_0_sa515_DNAJC3_Cytoplasm: DNAJC3_rna
$path_0_sa57_ATF6_Golgi: ((ATF6_Endoplasmic_Reticulum & ER_space_Stress_phenotype) & !retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype)
$path_0_sa583_ITPR_Endoplasmic_Reticulum: ((TMBIM6 | path_0_sa625_ERO1A_Endoplasmic_Reticulum) & path_0_sa582_ITPR_Endoplasmic_Reticulum)
$path_0_sa62_ATF6_Golgi: (path_0_sa57_ATF6_Golgi & MBTPS1)
$path_0_sa630_DDIT3_phosphorylated_Cytoplasm: (path_0_sa629_DDIT3_Cytoplasm & path_0_sa43_MAPK14_phosphorylated_Cytoplasm)
$path_0_sa64_ATF6_Golgi: (path_0_sa62_ATF6_Golgi & MBTPS2)
$path_0_sa69_DDIT3_Cytoplasm: DDIT3_rna
$path_0_sa95_GTP_simple_molecule_Cytoplasm: (Ternary_space_Complex_complex & path_0_sa103_GDP_simple_molecule_Cytoplasm)
$path_1_sa55_Ca2__ion_mitochondrion_outer_space_membrane: (((ITPR3_HSPA9_VDAC1_complex | ITPR3_HSPA9_VDAC1_complex) | SIGMAR1_ITPR3_complex) & path_1_sa54_Ca2__ion_Endoplasmic_Reticulum)
$path_1_sa87_HSPA5_Endoplasmic_Reticulum: (((ER_space_stress_phenotype | Ca2_space_ER_space_depletion_phenotype) & SIGMAR1_HSPA5_complex) | ((HSPA5_rna & ER_space_stress_phenotype) & !ACE2))
$protein_space_ubiquitination_space_and_space_destruction_phenotype: retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype
$pulmonary_fibrosis_phenotype: !ACE2
$release_space_of_space_ER_space_Ca2__phenotype: BAX_phosphorylated
$retrograde_space_transport_space_from_space_ER_space_to_space_cytosol_phenotype: (ATF6_Endoplasmic_Reticulum | EIF2AK3_EIF2AK3_complex)
$unfolded_space_protein_space_response_space__UPR__phenotype: ((ER_space_stress_phenotype | MFN2_Endoplasmic_Reticulum) | p20)
$viral_RNA_genome_replication_phenotype: ACE2
$viral_entry_into_host_cell_phenotype: (((ACE2_SARS_CoV_interaction_complex & SARS_CoV_infection_phenotype) | !ACE2__space_soluble) | HSPA5_Spike_interaction_complex)